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Toxic Epidermal Necrolysis

Visibly similar to SJS, Toxic Epidermal Necrolysis (TEN) occurs when approximately 30% or more of the body is covered in rash and blisters. SJS/TEN can begin with symptoms such as aching, fever, or headache. These symptoms may be followed by a rash that spreads across the body. The rash often evolves into blisters, which migrate together to separate the skin from the body. In severe cases, the skin begins to slough off and peel away, leaving the body exposed to infection.

The entire body can be affected, as well as the eye area and mucosal membranes. Stevens Johnson Syndrome / Toxic Epidermal Necrolysis reactions resemble burn injuries. As a result, patients who suffer these adverse drug reactions are susceptible to the same complications as burn patients; most notably, infections that seize on the lack of protection of the body which results from the loss of skin. For these reasons, SJS/TEN cases are best treated in a hospital burn center where patients can receive medical care from burn specialists.