Phenytoin Side Effects

Phenytoin has been investigated as a treatment for more than 100 diseases. A Medline search in November of 2002 showed that 12,860 articles concerning it have been published since 1966. In dermatology, phenytoin has been investigated to treat ulcers, epidermolysis bullosa, and inflammatory conditions. Numerous allergic, and proliferative, idiosyncratic cutaneous side effects have been reported with its use. This review summarizes its uses, mechanisms, and cutaneous side effects.

1. Silverman AK, Fairley J, Wong RC. Cutaneous and immunologic reactions to phenytoin. J Am Acad Dermatol. 1988;18:721-41.