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Dilantin Causes Brain Atrophy

Dilantin Brain Atrophy Warning

Dilantin Brain Atrophy

Dilantin Long - Term Drug Effects


Cerebral atrophy and skull thickening due to chronic phenytoin therapy

What is Cerebellar atrophy a generalized thickening of the skull vault has been seen in patients using Dilantion (phenytoin) long - term.

 

Cerebral atrophy is shrinkage of the brain, sometimes affecting the whole brain or just part of it and it can occur by long term use of Dilantin.

 

Cerebellar atrophy, or loss of brain issue in the cerebellum, may be caused by long-term use of Dilantin, particularly with use of high doses.

 

The side effect of phenytoin on skull thickening have long been recognized. Phenytoin has recently been shown to stimulate osteoblast proliferation and differentiation via upregulation of transforming growth factor-β1 and bone morphogenetic proteins.

The exact incidence of calvarial thickening is unknown, but has been reported to be 34% among patients with seizure disorder in institutions.

 

 

The clinical implications of skull thickening appear to be largely cosmetic: the degree of skull thickening correlates with frontal bossing (acromegaloid features with normal hand and foot size) and the degree of facial coarsening.

 

 

Dilantin Brain Atrophy

Dilantin Long - Term Drug Effects

Cerebral atrophy and skull thickening due to chronic phenytoin therapy

Cerebellar atrophy and generalized thickening of the skull vault has been seen in patients using Dilantion (phenytoin) long - term.

Cerebral atrophy is shrinkage of the brain, sometimes affecting the whole brain or just part of it and it can occur by long term use ofDilantin.

Cerebellar atrophy, or loss of brain issue in the cerebellum, may be caused by long-term use ofDilantin, particularly with use of high doses.